IOCB Prague

Norbert Weiss Group

Ion Channels and Diseases
Research Group
BIO cluster

About our group

Norbert Weiss Group was terminated as of 31 December 2020. The content of this page is no longer updated and serves for archive purposes only.

Voltage-gated-calcium channels are the primary mediators of the depolarization-induced calcium entry into neurons that initiates many cellular events. While calcium channels are of critical importance for neuronal function, it is also apparent that inappropriate expression or dysfunction gives rise to a variety of neurological disorders.

We investigate the intrinsic gating processes, as well as cell signaling pathways that control channel activity and trafficking to and from the plasma membrane, and how these regulations are compromised in disease states or by genetic mutations. Specifically, we focus on the subfamily of T-type calcium channels that are implicated in several neurological conditions, including neuropathic pain and epilepsy.