Research
Using a multidisciplinary approach, including patch clamp electrophysiology, molecular biology, biochemistry, confocal imaging microscopy, and rodent models, we investigate:
POST-TRANSLATIONAL REGULATION OF T-TYPE CHANNELS
We analyze the importance of post-translational modifications, especially glycosylation and phosphorylation, on the trafficking and function of the channel, and how these regulations are compromised by metabolic conditions (diabetes and homocysteinemia) leading to secondary neuronal disorders such as peripheral neuropathic pain.
GENETIC CHANNELOPATHIES OF T-TYPE CHANNELS
In collaboration with geneticists and physicians, we investigate the consequence and underlying mechanisms by which genetic mutations in the genes encoding for T-type channels alter channel function to provide structure/function/phenotype information to inherited T-type channelopathies.